Using Multiple Mouse on a Multiple Monitor Windows Computer is quick and easy. All you need to do is connect multiple Mouse / Pointing Devices to your Windows Computer and the Operating System takes care of the rest. The given below screenshot displays a Windows Computer with 2 Mice connected and both work to control a single Mouse Cursor. Using Multiple Mouse or Pointing Devices can be handy when you want to control the Windows Computer from multiple Locations or when multiple humans want to control the Computer and yes there can be other reasons as well.
The above Screenshot displays 2 Mouse connected on a Windows Computer. Since this Screenshot was taken on a Gaming Computer, both the Mice are used for Gaming purpose with one being the Logitech Optical Gaming Mouse G300 and other being the Gaming Mouse Software used for Automated Mouse Clicking. Note that there are actually 2 physical Mice connected to this Windows Computer and each is used for a different purpose.
Now looking at the Display Settings of the same Windows 10 Computer, we can see that this is a Dual Monitor Windows Computer with 2 Display Devices connected in Extended Mode. Note that the Number 1 Device is called as Primary Display Device and all other Display Devices are called as Secondary Display Devices. In Extended Mode, the actual available screen area spans across all the Display Devices. On this Computer both the Display Devices are Computer Monitors and the Second Monitor is placed to the Right of Primary or First Monitor. Moving Mouse from 1 Monitor to Second Monitor is simple task of Moving the Mouse Cursor towards Second Monitor and the Mouse Cursor jumps Monitors easily.
To Summarize using Multiple Mouse or Pointing Devices on a Multiple Monitor Windows Computer is almost the same as using Mice on a Single Monitor Windows Computer with the exception that on Multiple Monitor Windows Computer, the Mouse Cursor can be moved in an adjustable direction as controlled by Monitor Position defined in Display Settings. When you want to have Multiple Mouse or Pointing Devices connected to your Single or Multiple Monitor Windows Computer, you can even consider having Wireless Mouse Controls so as to avoid the hassles of Wires connecting Mice and the Windows Computer.